Higher baseline copper levels are associated with worse outcome in burn patients with overweight and obesity
| Autor: | Sheila Chandrahas, Kaylee Schrader, John A. Griswold, Chathurika S. Dhanasekara, Genesy Aickareth, Sharmila Dissanaike |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male medicine.medical_specialty Demographics Adverse outcomes Overweight Critical Care and Intensive Care Medicine Body Mass Index Internal medicine medicine Humans Obesity Copper levels Baseline (configuration management) Retrospective Studies business.industry General Medicine Length of Stay Middle Aged medicine.disease Normal weight Emergency Medicine Surgery medicine.symptom Burns business Body mass index Copper |
| Zdroj: | Burns. 48:1246-1252 |
| ISSN: | 0305-4179 |
| Popis: | We examined the interactive effects of copper (Cu) and overweight (overweight) and obesity on outcomes of burn patients. We posited that higher baseline Cu among burn patients with overweight or obesity will be associated with poor clinical outcomes vs. patients with a normal weight.A retrospective review was conducted on patients with ≥20% total burn surface area (TBSA) with an initial measurement of Cu. Patients were grouped by body mass index (BMI). The interactions between baseline Cu and BMI groups on multiple burn patient outcomes were examined in a series of multiple regression models.One-hundred-and-sixty patients met eligibility (age 43.9 ± 17.5, males 86.3%, normal weight:overweight:obesity = 53:38:69). BMI groups did not differ significantly on demographics, burn severity, or baseline biochemistry. Normal weight patients with higher baseline Cu had shorter ICU stay (ICUS), shorter length of stay (LOS), and had fewer operations (Ps0.05). In contrast, overweight and obese patients with higher baseline Cu had longer ICU stay (p = 0.001 and p = 0.034), LOS (p = 0.005 and p = 0.066), and increased operations (p = 0.001 and p = 0.067).Higher baseline Cu seems associated with adverse outcomes in overweight and obese burn patients. Further research is needed to confirm this association and explore the direction of causality. |
| Databáze: | OpenAIRE |
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