Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury
| Autor: | Kate A. Yurgil, Imanuel Lerman, Sharon Nichols, Deborah L. Harrington, Zhengwei Ji, Carl Rimmele, Royce E Clifford, Dewleen G. Baker, Annemarie Angeles-Quinto, Angela Drake, Jeffrey W Huang, Ashley Robb-Swan, Mingxiong Huang, Chung-Kuan Cheng, Charles Huang, Roland R. Lee, Tao Song, Lu Le |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Warfare medicine.medical_specialty Interneuron Traumatic brain injury Cognitive Neuroscience Ventromedial prefrontal cortex Neuropsychological Tests Audiology Cellular and Molecular Neuroscience Neuroimaging Neural Pathways medicine Gamma Rhythm Humans Brain Concussion Resting state fMRI medicine.diagnostic_test business.industry Brain Magnetoencephalography Cognition medicine.disease medicine.anatomical_structure business Neurocognitive |
| Zdroj: | Cerebral Cortex. 30:283-295 |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhz087 |
| Popis: | Combat-related mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members and veterans. Recent animal studies show that GABA-ergic parvalbumin-positive interneurons are susceptible to brain injury, with damage causing abnormal increases in spontaneous gamma-band (30–80 Hz) activity. We investigated spontaneous gamma activity in individuals with mTBI using high-resolution resting-state magnetoencephalography source imaging. Participants included 25 symptomatic individuals with chronic combat-related blast mTBI and 35 healthy controls with similar combat experiences. Compared with controls, gamma activity was markedly elevated in mTBI participants throughout frontal, parietal, temporal, and occipital cortices, whereas gamma activity was reduced in ventromedial prefrontal cortex. Across groups, greater gamma activity correlated with poorer performances on tests of executive functioning and visuospatial processing. Many neurocognitive associations, however, were partly driven by the higher incidence of mTBI participants with both higher gamma activity and poorer cognition, suggesting that expansive upregulation of gamma has negative repercussions for cognition particularly in mTBI. This is the first human study to demonstrate abnormal resting-state gamma activity in mTBI. These novel findings suggest the possibility that abnormal gamma activities may be a proxy for GABA-ergic interneuron dysfunction and a promising neuroimaging marker of insidious mild head injuries. |
| Databáze: | OpenAIRE |
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