Central nervous system vasculitis after chickenpox--cause or coincidence?
| Autor: | J. M. Freeman, E. P.G. Vining, A. Shuper |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Vasculitis Pathology medicine.medical_specialty Hemiplegia medicine.disease_cause Chickenpox Cerebrospinal fluid medicine Humans Child Brain Diseases medicine.diagnostic_test Cerebral infarction business.industry Brain biopsy Varicella zoster virus Cerebral Infarction medicine.disease Pediatrics Perinatology and Child Health Angiography business Research Article Cerebral angiography |
| Zdroj: | Archives of Disease in Childhood. 65:1245-1248 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.65.11.1245 |
| Popis: | A 7.5 year old boy, known to have a seizure disorder, presented with an infarct in the left middle cerebral artery territory, 10 weeks after severe chickenpox. Immunofluorescent antibody titre to the varicella zoster virus in the cerebrospinal fluid was 1:32. Cerebral angiography showed evidence of focal vasculitis. He presented again seven months later with an acute exacerbation of seizures. Magnetic resonance imaging of the brain showed an old posterior extension of the infarct, but a repeated angiography demonstrated an improvement in the vasculitic process. Cerebrospinal fluid antibody titre was again 1:32. Although this may have been an unfortunate coincidence, a possible association between chickenpox and vasculitis, similar to that reported with herpes zoster, and with potentially significant clinical implications, should be considered. As a definite proof can be obtained only by a brain biopsy, however, which is generally not indicated in such cases, only additional clinical reports can lead to delineation of this association as a definite entity. |
| Databáze: | OpenAIRE |
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