Plasma acetone metabolism in the fasting human
| Autor: | O E Owen, Pavle Paul, C. P. Holroyde, George A. Reichard, Agnes C. Haff, Charles L. Skutches |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Acetone metabolism Kinetics Endogeny Urine Ketone Bodies Glucose production Acetone chemistry.chemical_compound Internal medicine medicine Humans Obesity Chromatography General Medicine Metabolism Fasting Articles Carbon Dioxide Middle Aged Endocrinology chemistry Carbon dioxide Female |
| Zdroj: | The Journal of clinical investigation. 63(4) |
| ISSN: | 0021-9738 |
| Popis: | The metabolism of acetone was studied in lean and obese humans during starvation ketosis. Acetone concentrations in plasma, urine, and breath; and rates of endogenous production, elimination in breath and urine, and in vivo metabolism were determined. There was a direct relationship between plasma acetone turnover (20-77 mumol/m(2) per min) and concentration (0.19-1.68 mM). Breath and urinary excretion of acetone accounted for a 2-30% of the endogenous production rate, and in vivo metabolism accounted for the remainder. Plasma acetone oxidation accounted for congruent with60% of the production rate in 3-d fasted subjects and about 25% of the production rate in 21-d fasted subjects. About 1-2% of the total CO(2) production was derived from plasma acetone oxidation and was not related to the plasma concentration or production rate. Radioactivity from [(14)C]acetone was not detected in plasma free fatty acids, acetoacetate, beta-hydroxybutyrate, or other anionic compounds, but was present in plasma glucose, lipids, and proteins. If glucose synthesis from acetone is possible in humans, this process could account for 11% of the glucose production rate and 59% of the acetone production rate in 21-d fasted subjects. During maximum acetonemia, acetone production from acetoacetate could account for 37% of the anticipated acetoacetate production, which implies that a significant fraction of the latter compound does not undergo immediate terminal oxidation. |
| Databáze: | OpenAIRE |
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