Toxoplasma gondii infection induces the formation of host’s nuclear granules containing poly(A)-binding proteins
| Autor: | Karlee Fischer, Sirinart Ananvoranich, Mikayla Roberts, Yasin Avci, Scott Roscoe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030106 microbiology Immunology Poly(A)-Binding Proteins Applied Microbiology and Biotechnology Microbiology Viral infection Host-Parasite Interactions 03 medical and health sciences parasitic diseases Poly(A)-binding protein Genetics medicine Animals Humans Parasite hosting Molecular Biology Cell Nucleus biology Host (biology) Chemistry Toxoplasma gondii Biological Transport Translation (biology) General Medicine biology.organism_classification Pyrimethamine 030104 developmental biology medicine.anatomical_structure biology.protein Toxoplasma Nucleus Toxoplasmosis medicine.drug |
| Zdroj: | Canadian Journal of Microbiology. 64:551-558 |
| ISSN: | 1480-3275 0008-4166 |
| DOI: | 10.1139/cjm-2017-0755 |
| Popis: | To study the mechanism by which human host cells respond to an infection of Toxoplasma gondii, we monitored the level of poly(A)-binding protein (PABP), an indicator of translation. Here, we report an observation of the relocalization of PABPs in human host cells upon T. gondii infection. Notably, the aggregates of PABPs formed upon infection are mainly found in the nucleus, which is a different response from that found after exposure to heat shock. Pyrimethamine treatment of the infected monolayers inhibits the multiplicity of the parasite and reverses the relocalization of PABP aggregates. This active interaction between the infected mammalian host cells and T. gondii appears to be different from that caused by viral infection. |
| Databáze: | OpenAIRE |
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