New observations regarding Helicobacter pylori and gastric cancer in Mongolia
| Autor: | Takeshi Matsuhisa, Yansan Erdene-Ochir, Boldbaatar Gantuya, Duger Davaadorj, Tegshee Tserentogtokh, Yoshio Yamaoka, Ruvjir Sanduijav, Khasag Oyuntsetseg, Tomohisa Uchida, Dashdorj Bolor, Dashdorj Azzaya |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroenterology Endoscopy Gastrointestinal Article Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine medicine Humans CagA Ingestion Risk factor Aged Helicobacter pylori biology business.industry Stomach Incidence (epidemiology) digestive oral and skin physiology Cancer Histology Mongolia General Medicine Middle Aged biology.organism_classification medicine.disease digestive system diseases Infectious Diseases medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology business |
| Zdroj: | Helicobacter. 23:e12491 |
| ISSN: | 1083-4389 |
| DOI: | 10.1111/hel.12491 |
| Popis: | Background The incidence and mortality of gastric cancer in Mongolia is among the highest in the world. Methods This was a case-control study in which upper gastrointestinal endoscopy, gastric histology, Helicobacter pylori testing, and risk factor questionnaires were obtained. Histologic subtypes were determined by Lauren's classification. Results We enrolled 45 gastric cancer and 108 non-gastric cancer patients. Gastric cancers were located in upper part of stomach in 53.3%, main gastric body in 37.8%, and lower part of stomach in 8.9%. The majority (60%) were diffuse type, followed by intestinal type (36.7%) and indeterminate type (3.3%). H. pylori infections were CagA positive in 100% with cancer vs 81% without cancer (P = .02). The majority of CagA was non-East Asian type (95% with cancer and 94.1% without cancer). Cancer patients had typically related with excessive use of salt, hot beverages, tobacco smoking, and low ingestion of fruits. Conclusion The characteristic topography of gastric cancer in Mongolia being in the gastric corpus differed from East Asian countries and was more similar to western countries. The risk factors for gastric cancer in Mongolia were similar to other high-risk areas (ie, H. pylori infection, excessive use of salt, tobacco smoking, and low ingestion of fruits). |
| Databáze: | OpenAIRE |
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