Differential effect of high-fat, high-sucrose and combined high-fat/high-sucrose diets consumption on fat accumulation, serum leptin and cardiac hypertrophy in rats
| Autor: | J U Camacho Liévano, M F Hernández-Landero, Eduardo Martínez-Abundis, Nancy Patricia Gómez-Crisóstomo, E N De la Cruz-Hernández, E R Méndez Méndez |
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| Rok vydání: | 2018 |
| Předmět: |
Leptin
Male medicine.medical_specialty Physiology Dietary Sugars 030209 endocrinology & metabolism Cardiomegaly Fructose Diet High-Fat Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Risk Factors Physiology (medical) Internal medicine medicine Animals Obesity Rats Wistar Pathological Triglycerides Leptin receptor business.industry General Medicine High fat high sucrose Overweight medicine.disease Rats Endocrinology Adipose Tissue 030220 oncology & carcinogenesis Cardiac hypertrophy Serum leptin business Energy Intake |
| Zdroj: | Archives of physiology and biochemistry. 126(3) |
| ISSN: | 1744-4160 |
| Popis: | The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity. Only the HS group showed increased triglycerides levels after four months. Increased leptin levels were observed in HS and HF groups without changes on cardiac hypertrophy; on the opposing, HSHF group presented hypertrophy without the changes in serum leptin. The three experimental groups showed a decreased expression of leptin receptors ObR-b. In our results, the kind of diet for the induction of obesity is relevant for the outcome of the pathological profile. |
| Databáze: | OpenAIRE |
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