Regulation of peripheral vascular tone in patients with heart failure:Contribution of angiotensin II
| Autor: | David E. Newby, Keith A.A. Fox, Nicholas E. R. Goodfield, Andrew D. Flapan, Nicholas A. Boon, D J Webb |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Vasodilation Losartan Prehypertension Angiotensin Receptor Antagonists Norepinephrine Internal medicine Heart rate medicine Humans Infusions Intra-Arterial Vasoconstrictor Agents In patient Antihypertensive Agents Heart Failure Lower Body Negative Pressure Analysis of Variance Endothelin-1 business.industry Angiotensin II Middle Aged medicine.disease Vascular tone Peripheral Plethysmography Forearm Endocrinology Blood pressure Regional Blood Flow Heart failure Papers Cardiology Female Vascular Resistance medicine.symptom business Cardiology and Cardiovascular Medicine Vasoconstriction medicine.drug |
| Zdroj: | Newby, D E, Webb, D J, Flapan, A D, Boon, N A, Fox, K A A & Goodfield, N E R 1998, ' Regulation of peripheral vascular tone in patients with heart failure : Contribution of angiotensin II ', Heart, vol. 80, no. 2, pp. 134-141 . https://doi.org/10.1136/hrt.80.2.134 |
| DOI: | 10.1136/hrt.80.2.134 |
| Popis: | Objective—To determine directly the contribution of angiotensin II to basal and sympathetically stimulated peripheral arteriolar tone in patients with heart failure. Design—Parallel group comparison. Subjects—Nine patients with New York Heart Association grade II-IV chronic heart failure, and age and sex matched controls. Interventions—Forearm plethysmography, lower body negative pressure, local intra-arterial administration of losartan, angiotensin II, and noradrenaline, and estimation of plasma hormone concentrations. Main outcome measures—Forearm blood flow responses, plasma hormone concentrations. Results—Baseline blood pressure, heart rate, and forearm blood flow did not differ between patients and controls. In comparison with the non-infused forearm, losartan did not affect basal forearm blood flow (95% confidence interval −5.5% to +7.3%) or sympathetically stimulated vasoconstriction in controls. However, the mean (SEM) blood flow in patients increased by 13(5)% and 26(7)% in response to 30 and 90 µg/min of losartan respectively (p |
| Databáze: | OpenAIRE |
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