The Clinical Significance of Serum MASP-2 and IDH1 in the Early Diagnosis of Non-Small Cell Lung Cancer
| Autor: | Yan Chen, Wan-Qiu Bai, Shang Ma, En-Dong Wu, Yan-Jun Yin, Guang-Li Shi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms IDH1 Gastroenterology General Biochemistry Genetics and Molecular Biology Antigens Neoplasm Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor medicine Humans Clinical significance Lung cancer Early Detection of Cancer Tumor marker Keratin-19 Lung Receiver operating characteristic business.industry medicine.disease Isocitrate Dehydrogenase respiratory tract diseases Isocitrate dehydrogenase medicine.anatomical_structure Mannose-Binding Protein-Associated Serine Proteases Non small cell business |
| Zdroj: | Clinical Laboratory. 66 |
| ISSN: | 1433-6510 |
| Popis: | BACKGROUND The lack of effective means for the early diagnosis of non-small cell lung cancer (NSCLC) is the leading cause of the high mortality of NSCLC. This study aims to evaluate the clinical significance of serum mannan-binding lectin associated serine protease (MASP)-2 and isocitrate dehydrogenase 1 (IDH1) in the early diagnosis of NSCLC. METHODS The serum levels of MASP-2 and IDH1 were detected in 139 NSCLC patients, 46 patients with benign lung diseases and 61 healthy controls, using an enzyme linked immunosorbent method. The diagnostic significance in NSCLC of the two tumor markers were analyzed by receiver operating characteristic (ROC) curves. In addition, we compared the two markers with the current commonly used tumor marker cytokeratin 19 fragment (Cy¬fra21-1). RESULTS The serum levels of MASP-2 and IDH1 in the NSCLC patients were significantly higher than those of healthy controls and patients with benign lung diseases. The differences were statistically significant (p < 0.01). The combined sensitivity of MASP-2, IDH1, and Cyfra21-1 in the NSCLC was 68.3%, which was significantly higher than that of the single tumor marker (p < 0.01). The sensitivities of MASP-2 and IDH1 in detecting early NSCLC (stage I and stage II) were 39.0% and 41.5%, which were significantly higher than that of Cyfra21-1 (p < 0.05). The area under the ROC curves (AUCs) of MASP-2 and IDH1 in the diagnosis of NSCLC were 0.621, and 0.840, which were higher than that of Cyfra21-1 (AUC = 0.606). CONCLUSIONS Serum MASP-2 and IDH1 may be used as potential tumor markers for the auxiliary diagnosis and early diagnosis of NSCLC. |
| Databáze: | OpenAIRE |
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