Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle
| Autor: | Bijo Mathew, Jobin Jose, Md. Sahab Uddin, Della Grace Thomas Parambi, Aaron Mathew Thomas, Mohammad M. Al-Sanea, R Narayana Charyulu, Darewin Mendonsa |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Drug Biocompatible polymers Polymers Computer science Aptamer media_common.quotation_subject Clinical Biochemistry Biocompatible Materials Nanotechnology 02 engineering and technology Preparation method 03 medical and health sciences Drug Discovery Animals Humans media_common Pharmacology Drug discovery Aptamers Nucleotide 021001 nanoscience & nanotechnology Nanomedicine 030104 developmental biology Drug Design Molecular Medicine 0210 nano-technology |
| Zdroj: | Current Drug Targets. 20:1624-1635 |
| ISSN: | 1389-4501 |
| Popis: | Implementation of novel and biocompatible polymers in drug design is an emerging and rapidly growing area of research. Even though we have a large number of polymer materials for various applications, the biocompatibility of these materials remains as a herculean task for researchers. Aptamers provide a vital and efficient solution to this problem. They are usually small (ranging from 20 to 60 nucleotides, single-stranded DNA or RNA oligonucleotides which are capable of binding to molecules possessing high affinity and other properties like specificity. This review focuses on different aspects of Aptamers in drug discovery, starting from its preparation methods and covering the recent scenario reported in the literature regarding their use in drug discovery. We address the limitations of Aptamers and provide valuable insights into their future potential in the areas regarding drug discovery research. Finally, we explained the major role of Aptamers like medical imaging techniques, application as synthetic antibodies, and the most recent application, which is in combination with nanomedicines. |
| Databáze: | OpenAIRE |
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