Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors
| Autor: | Philippe J. Sansonetti, Armelle Phalipon, Laurie Pinaud |
|---|---|
| Přispěvatelé: | Pathogénie microbienne moléculaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Chaire Microbiologie et Maladies infectieuses, Collège de France (CdF (institution)), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège de France - Chaire Microbiologie et Maladies infectieuses |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Salmonella Cell MESH: NF-kappa B Yersinia Adaptive Immunity medicine.disease_cause MESH: Shigella Type three secretion system Enteropathogenic Escherichia coli NF-κB and MAPK signaling pathways Type III Secretion Systems Homeostasis Shigella Cytoskeleton cell death and survival biology Effector MESH: Yersinia NF-kappa B host–pathogen cross-talk MESH: Enterohemorrhagic Escherichia coli Protein Transport Infectious Diseases medicine.anatomical_structure MESH: Homeostasis Enterohemorrhagic Escherichia coli Host-Pathogen Interactions Mitogen-Activated Protein Kinases Microbiology (medical) MESH: Protein Transport Microbiology 03 medical and health sciences MESH: Type III Secretion Systems Immune system Virology medicine MESH: Cytoskeleton Humans MESH: Salmonella MESH: Enteropathogenic Escherichia coli MESH: Humans cell cytoskeleton and trafficking MESH: Host-Pathogen Interactions biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification MESH: Mitogen-Activated Protein Kinases [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology 030104 developmental biology bacteria Bacteria MESH: Adaptive Immunity |
| Zdroj: | Trends in Microbiology Trends in Microbiology, Elsevier, 2018, 26 (4), pp.266-283. ⟨10.1016/j.tim.2018.01.010⟩ Trends in Microbiology, 2018, 26 (4), pp.266-283. ⟨10.1016/j.tim.2018.01.010⟩ |
| ISSN: | 1878-4380 0966-842X |
| Popis: | International audience; Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bacteria, including the human enteric pathogens Shigella, Salmonella, Yersinia, and enteropathogenic/enterohemorragic Escherichia coli (EPEC/EHEC). The emerging global view is that these T3SS-bearing pathogens share similarities in their ability to target key cellular pathways such as the cell cytoskeleton, trafficking, cell death/survival, and the NF-κB and MAPK signaling pathways. In particular, multiple host proteins are targeted in a given pathway, and different T3SS effectors from various pathogens share functional similarities. |
| Databáze: | OpenAIRE |
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