Application of DNA‐Alkylating Pyrrole‐Imidazole Polyamides for Cancer Treatment
| Autor: | Toshikazu Bando, Rina Maeda, Hiroshi Sugiyama |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Conjugated system
010402 general chemistry 01 natural sciences Biochemistry Proto-Oncogene Proteins p21(ras) chemistry.chemical_compound Neoplasms medicine Animals Humans Imidazole Pyrroles Antineoplastic Agents Alkylating Molecular Biology Pyrrole Chlorambucil 010405 organic chemistry Drug discovery Organic Chemistry Imidazoles Cancer DNA Telomere medicine.disease Combinatorial chemistry 0104 chemical sciences Nylons DNA Alkylation chemistry Molecular Medicine medicine.drug |
| Zdroj: | ChemBioChem. 22:1538-1545 |
| ISSN: | 1439-7633 1439-4227 |
| Popis: | Pyrrole-imidazole (PI) polyamides, which target specific DNA sequences, have been studied as a class of DNA minor-groove-binding molecules. To investigate the potential of compounds for cancer treatment, PI polyamides were conjugated with DNA-alkylating agents, such as seco-CBI and chlorambucil. DNA-alkylating PI polyamides have attracted attention because of their sequence-specific alkylating activities, which contribute to reducing the severe side effects of current DNA-damaging drugs. Many of these types of conjugates have been developed as new candidates for anticancer drugs. Herein, we review recent progress into research on DNA-alkylating PI polyamides and their sequence-specific action on targets associated with cancer development. |
| Databáze: | OpenAIRE |
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