A pilot study of the comparative efficacy of 100 Hz magnetic seizure therapy and electroconvulsive therapy in persistent depression
| Autor: | Kate E. Hoy, G. Downey, Zafiris J. Daskalakis, Paul B. Fitzgerald, Lenore E. Wambeek, Leo Chen, Susan McQueen, David Elliot, Anne Maree Clinton |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Pilot Projects behavioral disciplines and activities law.invention 03 medical and health sciences Depressive Disorder Treatment-Resistant 0302 clinical medicine Electroconvulsive therapy Physical medicine and rehabilitation Randomized controlled trial Double-Blind Method law Seizures Outcome Assessment Health Care medicine Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Electroconvulsive Therapy Aged Psychomotor learning business.industry Middle Aged Transcranial Magnetic Stimulation 3. Good health 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cognitive inhibition Magnetic seizure therapy Brain stimulation Female Verbal memory business human activities 030217 neurology & neurosurgery |
| Zdroj: | Depression and anxiety. 35(5) |
| ISSN: | 1520-6394 |
| Popis: | BACKGROUND Magnetic seizure therapy (MST) is a novel brain stimulation technique that uses a high-powered transcranial magnetic stimulation device to produce therapeutic seizures. Preliminary MST studies have found antidepressant effects in the absence of cognitive side effects but its efficacy compared to electroconvulsive therapy (ECT) remains unclear. The aim of this study was to investigate the therapeutic efficacy and cognitive profile of MST compared to standard right unilateral ECT treatment. METHODS Thirty-seven patients completed a course of at least nine ECT or MST treatments in a randomized double-blind protocol. Assessments of depression severity and cognition were performed before and after treatment. RESULTS No difference in the antidepressant effectiveness between the treatments was seen across any of the clinical outcome measures, although the overall response rates in both groups were quite low. In regards to cognition, following MST there were significant improvements in tests of psychomotor speed, verbal memory, and cognitive inhibition, with no reductions in cognitive performance. Following ECT there was significant improvement in only one of the cognitive inhibition tasks. With respect to the between-group comparisons, the MST group showed a significantly greater improvement on psychomotor speed than ECT. CONCLUSIONS MST showed similar efficacy to right unilateral ECT in patients with treatment-resistant depression without cognitive side effects but in a sample that was only of sufficient size to demonstrate relatively large differences in response between the two groups. Future research should aim to optimize the methods of MST administration and compare its efficacy to ECT in large randomized controlled trials. |
| Databáze: | OpenAIRE |
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