Peptides Stimulate Expression of Signal Molecules in Neuronal Cultures from Animals of Different Age
| Autor: | V. Kh. Khavinson, R. S. Umnov, N. S. Linkova |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Nervous system
chemistry.chemical_classification Aging biology Brain cortex Vimentin Peptide General Medicine Neuroprotection General Biochemistry Genetics and Molecular Biology Rats Cell biology medicine.anatomical_structure chemistry Cell culture medicine biology.protein Animals Serotonin Rats Wistar Peptides |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 157:701-704 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2646-2 |
| Popis: | Molecular mechanisms of the neuroprotective effect of peptide T-33 and cortexin were studied on organotypic cultures of the brain from young and old Wistar rats. The effective concentration of peptide T-33 stimulating proliferative activity of neurons considerably surpassed that of cortexin. Cortexin and peptide T-33 stimulated the expression of serotonin, Ki-67, and vimentin in cells of the brain cortex; peptide T-33 was most effective in this respect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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