Challenges in developing a consensus definition of neonatal sepsis
| Autor: | Eleanor J. Molloy, Sinno H.P. Simons, Joseph M. Bliss, Rebecca Finnegan, Matthew McGovern, Agnes van den Hoogen, Willem P. de Boode, Fleur M Keij, Eric Giannoni, Infection, Inflammation, Immunology, James L. Wynn, Marina Degtyareva, Joyce M. Koenig, Mark A. Turner, Tobias Strunk, Helmut Kuester, Jan Mazela, Irwin K M Reiss |
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| Přispěvatelé: | Pediatrics |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Consensus Population Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] MEDLINE Sepsis 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Medicine Humans Mass Screening Neonatology Intensive care medicine education Mass screening education.field_of_study Neonatal sepsis business.industry Organ dysfunction Clinical course Infant Newborn medicine.disease Prognosis Europe Treatment Outcome Pediatrics Perinatology and Child Health medicine.symptom Neonatal Sepsis business 030217 neurology & neurosurgery Biomarkers Infant Premature |
| Zdroj: | Pediatric Research, 88, 1, pp. 14-26 Pediatric Research, 88(1), 14-26. Lippincott Williams & Wilkins Pediatric Research, 88, 14-26 |
| ISSN: | 0031-3998 |
| Popis: | Item does not contain fulltext Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at present, there is no unified definition of neonatal sepsis. Existing consensus sepsis definitions within paediatrics are not suited for use in the NICU and do not address sepsis in the premature population. Many neonatal research and surveillance networks have criteria for the definition of sepsis within their publications though these vary greatly and there is typically a heavy emphasis on microbiological culture. The concept of organ dysfunction as a diagnostic criterion for sepsis is rarely considered in neonatal literature, and it remains unclear how to most accurately screen neonates for organ dysfunction. Accurately defining and screening for sepsis is important for clinical management, health service design and future research. The progress made by the Sepsis-3 group provides a roadmap of how definitions and screening criteria may be developed. Similar initiatives in neonatology are likely to be more challenging and would need to account for the unique presentation of sepsis in term and premature neonates. The outputs of similar consensus work within neonatology should be twofold: a validated definition of neonatal sepsis and screening criteria to identify at-risk patients earlier in their clinical course. IMPACT: There is currently no consensus definition of neonatal sepsis and the definitions that are currently in use are varied.A consensus definition of neonatal sepsis would benefit clinicians, patients and researchers.Recent progress in adults with publication of Sepsis-3 provides guidance on how a consensus definition and screening criteria for sepsis could be produced in neonatology.We discuss common themes and potential shortcomings in sepsis definitions within neonatology.We highlight the need for a consensus definition of neonatal sepsis and the challenges that this task poses. |
| Databáze: | OpenAIRE |
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