Transcranial direct current stimulation in the male mouse to promote recovery after stroke
| Autor: | Rudolf Graf, Anton Pikhovych, Maria Adele Rueger, Michael Schroeter, Gereon R. Fink, Esther Mahabir, Helene Luise Walter |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine medicine.medical_treatment Stimulation Transcranial Direct Current Stimulation Mouse Skull Mice Random Allocation 03 medical and health sciences 0302 clinical medicine Animals Medicine Electrodes Stroke Electric stimulation General Veterinary Transcranial direct-current stimulation business.industry Brain Recovery of Function medicine.disease Neuromodulation (medicine) Mice Inbred C57BL Disease Models Animal 030104 developmental biology Animal Science and Zoology business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Laboratory Animals. 50:212-216 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1177/0023677215610708 |
| Popis: | Transcranial direct current stimulation (tDCS) constitutes a promising approach for promoting recovery of function after stroke, although the underlying neurobiological mechanisms are unclear. To conduct translational research in animal models, stimulation parameters should not lead to neuronal lesions. Liebetanz et al. recommend charge densities for cathodal stimulation in rats, but parameters for mice are not established. We established tDCS in the wild-type mouse, enabling studies with genetically-engineered mice (GEM). tDCS equipment was adapted to fit the mouse skull. Using different polarities and charge densities, tDCS was safe to apply in the mouse where the charge density was below 198 kC/m2 for single or repeated stimulations. These findings are crucial for future investigations of the neurobiological mechanisms underlying tDCS using GEM. |
| Databáze: | OpenAIRE |
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