Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review
| Autor: | Jean Jenkins, Puneet Chawla Sahota, Carlton Haywood, Clinton H. Joiner, Rakhi P. Naik, Nkeiruka I. Umeh, Kathryn L. Hassell, Michele A. Lloyd-Puryear, Vence L. Bonham, Kim Smith-Whitley, Mariane de Montalembert, Gregory J. Kato |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty 030204 cardiovascular system & hematology Cochrane Library Article Rhabdomyolysis Sickle Cell Trait 03 medical and health sciences 0302 clinical medicine Postoperative Complications Risk Factors Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Risk factor Renal Insufficiency Chronic Child Stroke Sickle cell trait business.industry Body Weight General Medicine Publication bias medicine.disease Body Height Proteinuria Cardiovascular Diseases Exertional rhabdomyolysis Wounds and Injuries Observational study business Kidney disease |
| Popis: | Background Although sickle cell trait (SCT) is largely a benign carrier state, it may increase risk for certain clinical outcomes. Purpose To evaluate associations between SCT and clinical outcomes in children and adults. Data Sources English-language searches of PubMed, CINAHL, the Cochrane Library, Current Contents Connect, Scopus, and Embase (1 January 1970 to 30 June 2018) and bibliographies of review articles. Study Selection Observational controlled studies (published in English) in children or adults that examined an association between SCT and any of 24 clinical outcomes specified a priori in the following 6 categories: exertion-related injury; renal, vascular, pediatric, and surgery- or trauma-related outcomes; and overall mortality. Data Extraction A single reviewer extracted study data, which was checked by another; 2 reviewers independently assessed study quality; and strength of evidence was assessed by consensus. Data Synthesis Of 7083 screened studies, 41 met inclusion criteria. High-strength evidence supported a positive association between SCT and risk for pulmonary embolism, proteinuria, and chronic kidney disease. Moderate-strength evidence supported a positive association between SCT and exertional rhabdomyolysis and a null association between SCT and deep venous thrombosis, heart failure or cardiomyopathy, stroke, and pediatric height or weight. Absolute risks for thromboembolism and rhabdomyolysis were small. For the remaining 15 clinical outcomes, data were insufficient or strength of evidence was low. Limitation Publication bias was possible, and high-quality evidence was scant. Conclusion Sickle cell trait is a risk factor for a few adverse health outcomes, such as pulmonary embolism, kidney disease, and exertional rhabdomyolysis, but does not seem to be associated with such complications as heart failure and stroke. Insufficient data or low-strength evidence exists for most speculated complications of SCT. Primary Funding Source National Human Genome Research Institute. |
| Databáze: | OpenAIRE |
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