Serum level of major basic protein indicates disease activity in atopic dermatitis

Autor:	Motoaki Ozaki, Shigetoshi Sayama, Toshiyuki Aoshima, Tsuneo Mitani, Ikuko Furukawa, Sadao Imamura, Mitsuyoshi Omoto, Masami Uehara, Naoko Nakajima, Mari Sawami, Kouichi Ikai
Rok vydání:	1997
Předmět:	Ketotifen biology business.industry Radioimmunoassay Dermatology Atopic dermatitis Eosinophil medicine.disease Disease activity Infectious Diseases medicine.anatomical_structure Immunology medicine Major basic protein biology.protein business medicine.drug
Zdroj:	Journal of the European Academy of Dermatology and Venereology. 9:54-56
ISSN:	0926-9959
Popis:	We evaluated the serum levels of major basic protein (MBP), assayed using an MBP radioimmunoassay kit, and the effect of an anti-allergic agent, ketotifen, which has strong anti-eosinophil activity, in 56 atopic dermatitis (AD) patients. The serum MBP level was significantly lower (660.11 ± 34.52 ng/ml, P < 0.05) after administration of ketotifen (1 mg twice a day) for 8 weeks than before treatment (774.98 ± 48.64 ng/ml). These findings suggest that serum MBP levels are a useful indicator of AD activity and that anti-allergic agents can have an effect on eosinophil involvement in AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017418d7e8271dd95ddb10bd9d678a71 https://doi.org/10.1016/s0926-9959(97)00633-8 Zobrazit plný text záznamu Plný text