The BCL-2 Inhibitor Venetoclax Augments Immune Effector Function Mediated by Fas Ligand, TRAIL, and Perforin/Granzyme B, Resulting in Reduced Plasma Viremia and Decreased HIV Reservoir Size during Acute HIV Infection in a Humanized Mouse Model

Autor:	Aswath P. Chandrasekar, Nathan W. Cummins, Sekar Natesampillai, Anisha Misra, Alecia Alto, Greg Laird, Andrew D. Badley
Rok vydání:	2022
Předmět:	Virology Insect Science Immunology Microbiology
Zdroj:	Journal of Virology. 96
ISSN:	1098-5514 0022-538X
DOI:	10.1128/jvi.01730-22
Popis:	This study is the first to examine the applicability of BCL-2 inhibition in the setting of active HIV infectionin vivo. Furthermore, this study demonstrates that venetoclax significantly enhances target cell killing induced by Fas ligand, TRAIL, and perforin/granzyme B and synergistically enhances autologous NK and CD8 cells’ killing of target cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0170897b9c2d9cca127dbfd3aae46a59 https://doi.org/10.1128/jvi.01730-22 Zobrazit plný text záznamu