Pubertal immune challenge suppresses the hypothalamic-pituitary-gonadal axis in male and female mice
Autor: | Chantal Matar, Jeffrey D. Blaustein, Jacky Liang, Rajini Chandrasegaram, Jean-François Mallet, Kevin B. Smith, Nafissa Ismail, Emma Murray |
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Rok vydání: | 2021 |
Předmět: |
Lipopolysaccharides
Male 0301 basic medicine Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Lipopolysaccharide Hypothalamus Neuropeptide Hypothalamic–pituitary–gonadal axis Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Kisspeptin Internal medicine medicine Animals Kisspeptins business.industry General Neuroscience Luteinizing Hormone 030104 developmental biology Endocrinology Sexual dysfunction chemistry Female Follicle Stimulating Hormone medicine.symptom Luteinizing hormone business 030217 neurology & neurosurgery Receptors Kisspeptin-1 Hormone |
Zdroj: | Brain Research Bulletin. 170:90-97 |
ISSN: | 0361-9230 |
Popis: | Kisspeptin is a neuropeptide responsible for propagating the hypothalamic-pituitary-gonadal (HPG) axis and initiating puberty. Pubertal exposure to an immune challenge causes enduring sexual behavior dysfunction in males and females, but the mechanism underlying this stress-induced sexual dysfunction remains unknown. Previous findings show that stress exposure can downregulate the HPG axis in adult females. However, it is unclear whether stress induced HPG axis suppression is limited to adult females or also extends to males and to pubertal animal models. The current study was designed to investigate the sex-specific consequences of a pubertal immune challenge on specific components of the HPG axis. Six-week old pubertal male and female mice were treated with saline or with lipopolysaccharide, a bacterial endotoxin. Expression of hypothalamic Kiss1 and Kiss1R as well as serum concentrations of luteinizing hormone, follicle-stimulating hormone, and growth hormone were examined. Pubertal lipopolysaccharide treatment decreased hypothalamic Kiss1, but not Kiss1R, expression in both males and females. Furthermore, only males showed decreases in circulating luteinizing and follicle-stimulating hormones. These results show that pubertal immune challenge suppresses the HPG axis by inhibiting Kiss1 production and decreasing serum gonadotropin concentrations in pubertal males, but points to a different mechanism in pubertal females. |
Databáze: | OpenAIRE |
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