Role of cyclooxygenases in the stimulatory effect of carcinogen 1,2-dimethylhydrazine on stem cell survival in the intestinal epithelium and bone marrow
| Autor: | A. G. Konoplyannikov, S. Ya. Proskuryakov, L. P. Ulyanova, O. A. Konoplyannikova, A. F. Tsyb |
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| Rok vydání: | 2009 |
| Předmět: |
Cell Survival
Indomethacin Bone Marrow Cells Biology In Vitro Techniques General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Mice Intestinal mucosa Indometacin medicine Animals Cyclooxygenase Inhibitors Intestinal Mucosa Carcinogen Stem Cells General Medicine Intestinal epithelium 1 2-Dimethylhydrazine Haematopoiesis medicine.anatomical_structure chemistry Gamma Rays Prostaglandin-Endoperoxide Synthases Immunology Cancer research Carcinogens Bone marrow Stem cell medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 146(4) |
| ISSN: | 0007-4888 |
| Popis: | In vivo experimental studies showed that 1,2-dimethylhydrazine and product of its metabolism in the body azoximethane improve postradiation survival of two types of stem cells in the adult organism: hemopoietic stem cells and intestinal epithelial stem cells. This effect similar to the well-known radioprotective effect of E. coli lipopolysaccharide was observed, when the carcinogen was administered 1 day before gamma-irradiation. Treatment with 1,2-dimethylhydrazine prolonged the mean life-span of mice irradiated in supralethal doses inducing death of the majority of intestinal epithelial stem cells. Nonspecific cyclooxygenase inhibitor indometacin weakened this radioprotective effect of 1,2-dimethylhydrazine. We also found that carcinogen 1,2-dimethylhydrazine improved survival of hemopoietic stem cells. However, in contrast to intestinal epithelial stem cells, indometacin did not inhibit the radioprotective effect of the carcinogen. The radioprotective effect of 1,2-dimethylhydrazine and lipopolysaccharide on stem cells in the presence of indometacin was a sum of individual effects of these preparations and indometacin. |
| Databáze: | OpenAIRE |
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