Discrete white matter abnormalities at age 8–11 years in children born extremely preterm are not associated with adverse cognitive or motor outcomes

Autor: Nelly Padilla, Marika Strindberg, Gustaf Mårtensson, Hedvig Kvanta, Lina Broström, Maria Örtqvist, Ulrika Ådén, Nuno Canto Moreira, Daniela Nosko, Jan Svoboda
Rok vydání: 2021
Předmět:
Zdroj: Acta Paediatrica. 111:566-575
ISSN: 1651-2227
0803-5253
Popis: Aim Little is known about the prevalence of discrete white matter abnormalities (WMA) beyond the first years in children born extremely preterm (EPT) and the relation to neurodevelopmental outcomes. Our aim was to investigate the prevalence of discrete WMA in children born EPT and the relationship to neonatal WMI, white matter volume, white matter diffusivity and neurodevelopment. Methods The study was a part of a longitudinal follow-up study of EPT neonates. All children were scanned at Karolinska University hospital 2004-2007 (neonates) and 2014-2015 (children at 8-11 years). WMA was qualitatively assessed by visual inspection. Developmental assessment was conducted at 12 years. Results In total 112 children (median age 10.3 years, 56 girls) underwent MRI of the brain (68 EPT, 45 controls). In the EPT group, a subset had MRI around term equivalent age (n=61). In the EPT group, the prevalence of discrete WMA at 8-11 years was 52%. There was a positive association between white matter injuries (WMI) at TEA and 8-11 years. There was no association between WMI and WM volumes or diffusivity at 8-11 years. Discrete WMA was not related to neurodevelopmental outcomes. Conclusion Discrete WMA was prevalent in children born EPT at 8-11 years but were not related to neurodevelopmental outcomes.
Databáze: OpenAIRE