Discrete white matter abnormalities at age 8–11 years in children born extremely preterm are not associated with adverse cognitive or motor outcomes
Autor: | Nelly Padilla, Marika Strindberg, Gustaf Mårtensson, Hedvig Kvanta, Lina Broström, Maria Örtqvist, Ulrika Ådén, Nuno Canto Moreira, Daniela Nosko, Jan Svoboda |
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Rok vydání: | 2021 |
Předmět: |
Pediatrics
medicine.medical_specialty White matter Cognition medicine Humans Child medicine.diagnostic_test Term equivalent age business.industry Extremely preterm Infant Newborn Brain Magnetic resonance imaging General Medicine University hospital Magnetic Resonance Imaging White Matter medicine.anatomical_structure Infant Extremely Premature Pediatrics Perinatology and Child Health White matter abnormalities Female business Follow-Up Studies |
Zdroj: | Acta Paediatrica. 111:566-575 |
ISSN: | 1651-2227 0803-5253 |
Popis: | Aim Little is known about the prevalence of discrete white matter abnormalities (WMA) beyond the first years in children born extremely preterm (EPT) and the relation to neurodevelopmental outcomes. Our aim was to investigate the prevalence of discrete WMA in children born EPT and the relationship to neonatal WMI, white matter volume, white matter diffusivity and neurodevelopment. Methods The study was a part of a longitudinal follow-up study of EPT neonates. All children were scanned at Karolinska University hospital 2004-2007 (neonates) and 2014-2015 (children at 8-11 years). WMA was qualitatively assessed by visual inspection. Developmental assessment was conducted at 12 years. Results In total 112 children (median age 10.3 years, 56 girls) underwent MRI of the brain (68 EPT, 45 controls). In the EPT group, a subset had MRI around term equivalent age (n=61). In the EPT group, the prevalence of discrete WMA at 8-11 years was 52%. There was a positive association between white matter injuries (WMI) at TEA and 8-11 years. There was no association between WMI and WM volumes or diffusivity at 8-11 years. Discrete WMA was not related to neurodevelopmental outcomes. Conclusion Discrete WMA was prevalent in children born EPT at 8-11 years but were not related to neurodevelopmental outcomes. |
Databáze: | OpenAIRE |
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