In Vivo Bio-imaging Using Chlorotoxin-based Conjugates
| Autor: | Stacey Hansen, James M. Olson, Mark R. Stroud |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Diagnostic Imaging
Models Molecular medicine.medical_specialty Pathology Molecular Sequence Data Normal tissue Contrast Media Scorpion Venoms Biology Article Bio imaging chemistry.chemical_compound Optical imaging In vivo Drug Discovery medicine Medical imaging Animals Humans Amino Acid Sequence Fluorescent Dyes Pharmacology Intraoperative Care Brain Neoplasms Cancer medicine.disease Spectrometry Fluorescence Chlorotoxin chemistry Tumor progression Nanoparticles Radiology Protein Binding |
| Zdroj: | Current Pharmaceutical Design. 17:4362-4371 |
| ISSN: | 1381-6128 |
| Popis: | Surgical resection remains the primary component of cancer therapy. The precision required to successfully separate cancer tissue from normal tissue relies heavily on the surgeon's ability to delineate the tumor margins. Despite recent advances in surgical guidance and monitoring systems, intra-operative identification of these margins remains imprecise and directly influences patient prognosis. If the surgeon had improved tools to distinguish these margins, tumor progression and unacceptable morbidity could be avoided. In this article, we review the history of chlorotoxin and its tumor specificity and discuss the research currently being generated to target optical imaging agents to cancer tissue. |
| Databáze: | OpenAIRE |
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