Influence of omega-3 PUFAs on the metabolism of proanthocyanidins in rats
| Autor: | Marta Romeu, Núria Taltavull, Josep Lluís Torres, Sara Ramos-Romero, Eunice Molinar-Toribio, Isabel Medina, Lucía Méndez, Elisabet Fuguet, Jara Pérez-Jiménez |
|---|---|
| Přispěvatelé: | Farmacobiologia Cel.lular, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
food.ingredient Bioavailability Biological Availability 030209 endocrinology & metabolism Àcids grassos omega-3 Biology Rats Inbred WKY Feces 03 medical and health sciences 0302 clinical medicine food Phenols Tandem Mass Spectrometry Fatty Acids Omega-3 Omega-3 fatty acids Animals Proanthocyanidins Chromatography High Pressure Liquid Ciències de la salut chemistry.chemical_classification Biodisponibilitat 030109 nutrition & dietetics Health sciences Polyphenols food and beverages Metabolism Ciencias de la salud Eicosapentaenoic acid Gastrointestinal Microbiome Rats Biochemistry Proanthocyanidin chemistry Polyphenol Docosahexaenoic acid Polifenols Grape seed extract 0963-9969 Fermentation Female Proantocianidines Food Science Polyunsaturated fatty acid |
| Zdroj: | Europe PubMed Central Food Research International Digital.CSIC. Repositorio Institucional del CSIC instname Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2017.03.046 |
| Popis: | Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18 weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16.6 g/kg feed), proanthocyanidin-rich grape seed extract (0.8 g/kg feed) or both. A total of 39 microbial-derived metabolites and 16 conjugated metabolites were detected by HPLC-MS/MS either in urine or in the aqueous fraction of feces. An unexpected significant increase in many proanthocyanidin metabolites in urine and feces was observed in the group supplemented with ω-3 polyunsaturated fatty acids group as compared to the animals fed a standard diet, which contains a small amount of polyphenols. However, proanthocyanidin metabolites in rats given ω-3 polyunsaturated fatty acids and grape seed extract did not significantly differ from those in the group supplemented only with grape seed extract. It was concluded that ω-3 polyunsaturated fatty acids collaborate in the metabolism of polyphenols when present at low doses in the feed matrix, while the capacity of ω-3 polyunsaturated fatty acids to induce microbiota transformations when proanthocyanidins are present at high doses is not relevant compared to that of polyphenols themselves. |
| Databáze: | OpenAIRE |
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