Production and Semi-Automated Processing of 89Zr Using a Commercially Available TRASIS MiniAiO Module
| Autor: | Clarence Ronald Geyer, Vijay Gaja, Jacqueline Cawthray, Humphrey Fonge |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Small volume Elution Organic Chemistry Radiochemistry Oxalic acid Pharmaceutical Science High radiation Zirconium-89 radiolabelling 030218 nuclear medicine & medical imaging Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry chemistry Chemistry (miscellaneous) 030220 oncology & carcinogenesis Drug Discovery Molecular Medicine Physical and Theoretical Chemistry Purification methods automation |
| Zdroj: | Molecules Volume 25 Issue 11 Molecules, Vol 25, Iss 2626, p 2626 (2020) |
| ISSN: | 1420-3049 |
| Popis: | The increased interest in 89Zr-labelled immunoPET imaging probes for use in preclinical and clinical studies has led to a rising demand for the isotope. The highly penetrating 511 and 909 keV photons emitted by 89Zr deliver an undesirably high radiation dose, which makes it difficult to produce large amounts manually. Additionally, there is a growing demand for Good Manufacturing Practices (GMP)-grade radionuclides for clinical applications. In this study, we have adopted the commercially available TRASIS mini AllinOne (miniAiO) automated synthesis unit to achieve efficient and reproducible batches of 89Zr. This automated module is used for the target dissolution and separation of 89Zr from the yttrium target material. The 89Zr is eluted with a very small volume of oxalic acid (1.5 mL) directly over the sterile filter into the final vial. Using this sophisticated automated purification method, we obtained satisfactory amount of 89Zr in high radionuclidic and radiochemical purities in excess of 99.99%. The specific activity of three production batches were calculated and was found to be in the range of 1351&ndash 2323 MBq/µ mol. ICP-MS analysis of final solutions showed impurity levels always below 1 ppm. |
| Databáze: | OpenAIRE |
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