Cease-fire at the leading edge: New perspectives on actin filament branching, debranching, and cross-linking
| Autor: | Benjamin Smith, Bruce L. Goode, Dennis Breitsprecher, Jeff Gelles, Casey A. Ydenberg |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
biology
Microfilament Proteins Arp2/3 complex Actin remodeling macromolecular substances Cell Biology Actin cytoskeleton Article Cell biology Actin Cytoskeleton Actin remodeling of neurons Actin filament branching Cell Movement Structural Biology Formins biology.protein Biophysics Humans MDia1 Lamellipodium Cytoskeleton |
| Zdroj: | Cytoskeleton. 68:596-602 |
| ISSN: | 1949-3584 |
| Popis: | Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here we discuss how the controversy has led to a deeper consideration of the architecture of actin networks underlying cell migration, and has helped define new challenges that lie ahead. |
| Databáze: | OpenAIRE |
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