C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

Autor: Alexander I. Kostyukov, A. V. Maznychenko, I. V. Vereshchaka, Tomasz Tomiak, Bulgakova Nv, Uwe Ritter, O. A. Kyzyma, Iryna V. Mishchenko, Olga O. Gonchar, Peter Scharff, Y. Prylutskyy, Dmytro M Nozdrenko
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Antioxidant
medicine.medical_treatment
Pharmaceutical Science
Medicine (miscellaneous)
medicine.disease_cause
Applied Microbiology and Biotechnology
Antioxidants
0302 clinical medicine
Antioxidant system
chemistry.chemical_classification
Skeletal muscles fatigue
biology
Chemistry
Glutathione
medicine.anatomical_structure
Biochemistry
Catalase
Muscle Fatigue
Molecular Medicine
Fullerenes
medicine.symptom
Muscle contraction
Muscle Contraction
Muscle tissue
medicine.medical_specialty
Biomedical Engineering
Bioengineering
Oxidative stress markers
Injections
Intramuscular
Thiobarbituric Acid Reactive Substances
03 medical and health sciences
Internal medicine
medicine
TBARS
Animals
Rats
Wistar
Muscle
Skeletal
Reactive oxygen species
Muscle fatigue
C60 fullerene
Research
Hydrogen Peroxide
Rats
Oxidative Stress
030104 developmental biology
Endocrinology
Electrical stimulation
biology.protein
Nanoparticles
Reactive Oxygen Species
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Journal of Nanobiotechnology
ISSN: 1477-3155
Popis: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats. During fatigue development, we observed decrease in the muscle effort level before C60FAS administration. After the application of C60FAS, a slower effort decrease, followed by the prolonged retention of a certain level, was recorded. An analysis of the metabolic process changes accompanying muscle fatigue showed an increase in the oxidative stress markers H 2 O 2 (hydrogen peroxide) and TBARS (thiobarbituric acid reactive substances) in relation to the intact muscles. After C60FAS administration, the TBARS content and H 2 O 2 level were decreased. The endogenous antioxidant system demonstrated a similar effect because the GSH (reduced glutathione) in the muscles and the CAT (catalase) enzyme activity were increased during fatigue. C60FAS leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that C60FAS affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance.
Databáze: OpenAIRE
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