Norfriedelins A–C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)
| Autor: | Lei Shi, Jiang Han, Xu-Yang Li, Ming-Hua Qiu, Jie-Qing Liu, Ting-Zhao Li, Wei-Ming Zhang, Xing-Rong Peng |
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| Rok vydání: | 2013 |
| Předmět: |
food.ingredient
Molecular Structure Stereochemistry Organic Chemistry Molecular Conformation Crystallography X-Ray Inhibitory postsynaptic potential Biochemistry Acetylcholinesterase Triterpenes Norfriedelin B Inhibitory Concentration 50 chemistry.chemical_compound food chemistry Malpighia emarginata Ic50 values Cholinesterase Inhibitors Physical and Theoretical Chemistry Nuclear Magnetic Resonance Biomolecular Two-dimensional nuclear magnetic resonance spectroscopy Malpighiaceae |
| Zdroj: | Organic Letters. 15:1580-1583 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata. Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an alpha-oxo-beta-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 mu m, respectively. |
| Databáze: | OpenAIRE |
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