Epstein-Barr virus-associated anaplastic large cell lymphoma in renal transplant patients
| Autor: | Christopher Bunch, Andreas Tobler, Lore Theilkäs, Martin F. Fey, Bettina Borisch, J. S. Wainscoat, Kevin C. Gatter |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Herpesvirus 4 Human CD30 Adolescent Ki-1 Antigen Biology medicine.disease_cause Polymerase Chain Reaction Virus Postoperative Complications Antigens CD Antigens Neoplasm hemic and lymphatic diseases medicine Humans Anaplastic large-cell lymphoma B cell Nucleic Acid Hybridization General Medicine Gene rearrangement DNA Neoplasm medicine.disease Virology Epstein–Barr virus Immunohistochemistry Kidney Transplantation Lymphoma Blotting Southern medicine.anatomical_structure DNA Viral Cancer research Immunoglobulin heavy chain Lymphoma Large B-Cell Diffuse DNA Probes |
| Zdroj: | American journal of clinical pathology. 98(3) |
| ISSN: | 0002-9173 |
| Popis: | A novel association, Epstein–Barr virus-positive Ki-1 +/CD30+ anaplastic large cell non-Hodgkin’s lymphoma of B-cell phenotype in immunosuppressed renal transplant recipients is reported. Case 1 involved an aggressive clinical evolution, whereas case 2 followed a more ”benign” clinical course. Both lymphomas were Epstein–Barr virus-positive as assessed by in situ hybridization, Southern blot, polymerase chain reaction, and immunohistochemical analysis. Both lymphomas contained a single clonal Epstein–Barr virus terminal-repeat fragment. In case 1, clonality was confirmed by the detection of biallelic immunoglobulin (Ig) heavy chain gene rearrangement. Case 2 showed germline Ig genes at presentation and oligoclonal Ig heavy chain gene rearrangements at relapse. These results are consistent with the notion that anaplastic large cell lymphoma might arise in a B cell transformed by Epstein–Barr virus at a very early stage, before Ig gene rearrangement. The latter may occur later in the course of clonal evolution, thus permitting investigators to trace intermediate and late stages within a process of multistep lymphomagenesis and/or tumor progression. |
| Databáze: | OpenAIRE |
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