Solanum paniculatum root extract reduces diarrhea in rats
| Autor: | Clécio S. Ramos, Teresinha Gonçalves da Silva, Thelma M.G. da Silva, Jonh Aldson Bezerra Tenório, Dulciana S. do Monte |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Loperamide
lcsh:RS1-441 030226 pharmacology & pharmacy 01 natural sciences lcsh:Pharmacy and materia medica Pharmacology Toxicology and Pharmaceutics(all) 03 medical and health sciences chemistry.chemical_compound Jurubeba 0302 clinical medicine Chlorogenic acid In vivo medicine Potency Gastrointestinal mobility General Pharmacology Toxicology and Pharmaceutics Chronic diarrhea Feces Traditional medicine biology biology.organism_classification Solanum paniculatum 0104 chemical sciences 010404 medicinal & biomolecular chemistry Diarrhea Biochemistry chemistry Antidiarrheal activity medicine.symptom Solanaceae medicine.drug |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 26, Iss 3, Pp 375-378 (2016) Revista Brasileira de Farmacognosia, Volume: 26, Issue: 3, Pages: 375-378, Published: JUN 2016 Revista Brasileira de Farmacognosia, Vol 26, Iss 3, Pp 375-378 Revista Brasileira de Farmacognosia v.26 n.3 2016 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| Popis: | Solanum paniculatum L., Solanaceae, locally known as “jurubeba”, is widely used in Brazil for culinary purposes, and in folk medicine to treat of diverse disorder including gastric dysfunctions. In this study we investigated the antidiarrheal activity of S. paniculatum roots extract in rats at different concentrations (125, 250 and 500 mg/kg, p.o) using different experimental models such as castor oil-induced diarrhea, enteropooling and gastrointestinal motility, determined by in vivo experimental models. The major compound of root extract was characterized as chlorogenic acid based in the IR, 1D and 2D NMR analysis. All the extract doses achieved antidiarrheal potency, as indicated by reduced weight of feces in castor oil-induced diarrhea, decreased intestinal motility and significantly inhibited castor oil-induced enteropooling compared to the vehicle group. The highest dose (500 mg/kg) produced greater anti-motility effect and better reduction of enteropooling, similar to the reference drug Loperamide (5 mg/kg). Extract from S. paniculatum L. roots had antidiarrheal activity, as shown by the lower weight of the feces as well as decrease in the accumulation of intestinal fluid and slower transit, justifying the traditional use of plant for diarrhea. Keywords: Antidiarrheal activity, Chronic diarrhea, Chlorogenic acid, Gastrointestinal mobility, Jurubeba |
| Databáze: | OpenAIRE |
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