Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection
| Autor: | Kai Yang, Jie Shen, Minxia Zheng, Cai-hua Sun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Time Factors
Antioxidant medicine.medical_treatment correlation analysis education Pharmaceutical Science antioxidant activity Apoptosis Salvia miltiorrhiza hplc Chemical Fractionation Pharmacology High-performance liquid chromatography Antioxidants Protocatechuic acid law.invention Rats Sprague-Dawley chemistry.chemical_compound salvianolic acid law mental disorders Human Umbilical Vein Endothelial Cells medicine Animals Cells Cultured Chromatography High Pressure Liquid Pharmaceutical industry Active ingredient Plants Medicinal Plant Extracts Rosmarinic acid General Medicine chemistry Cytoprotection salvia miltiorrhiza injection Injections Intravenous Protocatechuic aldehyde Female HD9665-9675 Phytotherapy |
| Zdroj: | Acta Pharmaceutica, Vol 64, Iss 3, Pp 325-334 (2014) |
| ISSN: | 1846-9558 |
| Popis: | Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI). HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, protocatechuic acid and their metabolites in rat serum may contribute to the efficacy of SMI. Assessment of antioxidant properties indicated that differences in the composition of serum powder of SMI caused differences in vascular endothelial cell protection. When bivariate correlation was carried out it was found that salvianolic acid B, tanshinol and protocatechuic aldehyde were active components of SMI because they were correlated to antioxidant properties. |
| Databáze: | OpenAIRE |
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