Association study between HLA-A, -B, -C, -DRB1 alleles and Psoriatic arthritis in southern France
| Autor: | Emmanuel Massy, Pascal Pedini, Eloise Pollet, Marielle Martin, Jean Roudier, Christophe Picard, Nathalie Balandraud |
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| Přispěvatelé: | Institut du Mouvement et de l’appareil Locomoteur [Hôpital Sainte-Marguerite - APHM] (IML), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Arthrites autoimmunes (AA), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement Français du Sang PACA Corse [Marseille] (EFS PACA), Roudier, jean, Aix Marseille Université (AMU), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS) |
| Rok vydání: | 2021 |
| Předmět: |
[SDV.IMM] Life Sciences [q-bio]/Immunology
[SDV]Life Sciences [q-bio] HLA-C*06 Immunology [SDV.GEN] Life Sciences [q-bio]/Genetics HLA-C Antigens Psoriatic Arthritis Immunology and Allergy Humans Genetic Predisposition to Disease ComputingMilieux_MISCELLANEOUS Alleles Retrospective Studies [SDV.GEN]Life Sciences [q-bio]/Genetics [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology HLA-A Antigens HLA-B*27 Arthritis Psoriatic General Medicine HLA HLA-B Antigens [SDV.IMM]Life Sciences [q-bio]/Immunology France Genetic Background [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology HLA-DRB1 Chains |
| Zdroj: | Human Immunology Human Immunology, In press, 83, pp.515-520. ⟨10.1016/j.humimm.2022.04.001⟩ Human Immunology, Elsevier, In press, 83, pp.515-520. ⟨10.1016/j.humimm.2022.04.001⟩ Human Immunology, 2022, ⟨10.1016/j.humimm.2022.04.001⟩ |
| ISSN: | 1879-1166 0198-8859 |
| Popis: | International audience; Psoriatic arthritis (PsA) is a type of inflammatory arthritis associated with psoriasis. HLA association studies performed in northern Europe, comparing patients with control populations, have shown that the highest risk for PsA is carried by HLA-C*06, HLA-B*57 and HLA-B*27 alleles. This retrospective association study compared HLA-A, -B, -C, and -DR alleles of 500 patients from southern France, who fulfilled the CASPAR criteria for Psoriatic Arthritis (PsA), with 2346 controls from healthy blood donors, using the chi-square test. We classified PsA patients into three different subgroups according to disease: purely axial, purely peripheral and combined axial and peripheral. The 'axial' subgroup was associated with HLA-B*27 (OR = 16.3, p = 2.7 × 10-28) and its haplotypes: HLA- B*27-C*01 (OR = 12.4, p = 1.7 × 10-12) and HLA-B*27-C*02 (OR = 8.7, p = 10 × 10-9). The 'axial and peripheral' and the 'peripheral' subgroups were associated with HLA-C*06 (respectively OR = 1.5, p = 3.6 × 10-10 and OR = 2.4, p = 3.6 × 10-12) and its haplotypes HLA-C*06-B*13 (respectively OR = 2.4, p = 1.2 × 10-6 and OR = 2.8, p = 6.4 × 10-11). This association study on a southern French PsA cohort identifies HLA-C*06 as a marker for peripheral PsA and HLA-B*27 as a marker for purely axial PsA. |
| Databáze: | OpenAIRE |
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