Adjunctive subconjunctival mitomycin C in glaucoma triple procedure
| Autor: | Stephen Y. Reed, Man S. Song, Chaesik Kim, Piero A. Simone, Mark S Juzych, Bret A Hughes, Dong H. Shin |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty genetic structures Open angle glaucoma medicine.medical_treatment Eye disease Mitomycin Visual Acuity Glaucoma Intraocular lens Trabeculectomy Cataract Ophthalmology Medicine Humans Prospective Studies Intraocular Pressure Aged Lenses Intraocular Antibiotics Antineoplastic Phacoemulsification business.industry Mitomycin C medicine.disease eye diseases Surgery Chemotherapy Adjuvant Female sense organs business Conjunctiva Glaucoma Open-Angle Follow-Up Studies |
| Zdroj: | Ophthalmology. 102(10) |
| ISSN: | 0161-6420 |
| Popis: | To evaluate the potential benefit of adjunctive subconjunctival mitomycin in patients with primary open-angle glaucoma undergoing primary trabeculectomy combined with phacoemulsification and intraocular lens implantation.Seventy-eight eyes of 78 patients with primary open-angle glaucoma with visually symptomatic cataracts and no previous incisional surgery were randomized to receive either no mitomycin C or a subconjunctival application of 1-, 3-, or 5-minute mitomycin C (0.5 mg/ml).Follow-up (mean +/- standard deviation) was 21.0 +/- 7.7 months. The mean postoperative intraocular pressures were significantly lower with significantly less medications than the preoperative values at each follow-up time (1, 3, 6, 9, 12, 15 months, and last follow-up) for all groups (P0.05 for each). However, there was no significant difference at each follow-up time in intraocular pressure, medications, or best-corrected visual acuity among the four groups or between the control and the total mitomycin C group.Adjunctive subconjunctival mitomycin C did not further improve the final intraocular pressure outcome of the primary trabeculectomy combined with phacoemulsification and intraocular lens implantation in patients with primary open-angle glaucoma. Future studies will determine the appropriate role, if any, for adjunctive mitomycin C in selected primary glaucoma triple procedures. |
| Databáze: | OpenAIRE |
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