Cortical thickness and cognitive performance in asymptomatic unilateral carotid artery stenosis

Autor: Bastian Cheng, Felix Fischer, Andreas Niebuhr, Simon S Kessner, Marlene Heinze, Hans O. Pinnschmidt, Götz Thomalla, Christian Gerloff, Jens Fiehler, Alina Nickel, Julian Schröder, Axel Larena-Avellaneda, Caroline Malherbe
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Cognitive
Trail Making Test
030204 cardiovascular system & hematology
Asymptomatic
Cortical thickness
03 medical and health sciences
0302 clinical medicine
Cognition
Predictive Value of Tests
Internal medicine
medicine.artery
Medicine
Humans
Carotid Stenosis
Cognitive Dysfunction
Carotid artery stenosis
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
Angiology
Aged
Cerebral Cortex
business.industry
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Cardiac surgery
Stenosis
lcsh:RC666-701
Case-Control Studies
Middle cerebral artery
Stroop Test
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Stroop effect
Research Article
MRI
Zdroj: BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-6 (2019)
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Background We investigated changes of cortical thickness and its association with cognitive performance in patients with high-grade carotid artery stenosis without ischemic brain lesions. Methods We studied 25 patients with unilateral carotid artery stenosis ≥50% and 25 age-matched controls. All subjects underwent T1-weighted MRI, and cortical thickness was measured in 33 regions of interest in each hemisphere, as well as in brain regions belonging to the vascular territory of the middle cerebral artery (MCA). General linear mixed models were fitted to the dependent variable cortical thickness. Cognitive assessment comprised the Stroop Test and Trail Making Test B. Results In the linear mixed model, presence of carotid stenosis had no effect on cortical thickness. There was a significant interaction of stenosis and region with a trend towards lower cortical thickness in the MCA region on the side of carotid stenosis. Patients with carotid stenosis performed significantly worse on the Stroop test than controls, but there was no correlation with cortical thickness. Conclusion In patients with carotid stenosis without ischemic brain lesions, neither a clear pattern of reduced cortical thickness nor an association of cortical thickness with cognitive function was observed. Our data do not support the hypothesized association of cortical thinning and cognitive impairment in carotid stenosis. Electronic supplementary material The online version of this article (10.1186/s12872-019-1127-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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