Fatal Early Onset Infection in an Extremely Low Birth Weight Infant due to Morganella morganii
| Autor: | Gloria B. Valencia, Steve Piecuch, Sukhvinder S Ranu |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Fetal Membranes Premature Rupture Pediatrics medicine.medical_specialty Fatal outcome Penicillin Resistance Anti-Inflammatory Agents Penicillins Dexamethasone Fatal Outcome Pregnancy polycyclic compounds medicine Humans Pregnancy Complications Infectious Early onset Morganella morganii biology Infectious disease transmission business.industry Enterobacteriaceae Infections Infant Newborn Obstetrics and Gynecology Infant Low Birth Weight biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Infectious Disease Transmission Vertical Low birth weight Chorioamnionitis Penicillin resistance Pediatrics Perinatology and Child Health bacteria Ampicillin Female medicine.symptom Extremely low birth weight infant business |
| Zdroj: | Journal of Perinatology. 19:533-535 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/sj.jp.7200230 |
| Popis: | This paper reports a case of chorioamnionitis due to Morganella morganii in a mother who presented with ruptured membranes at 24 weeks' gestation and was treated with dexamethasone and prophylactic ampicillin. Her premature infant developed severe early onset infection due to the same organism and expired.A clinical case report of M. morganii infection complicating preterm rupture of membranes is presented. Possible risk factors for maternal and neonatal infection with this organism as well as the therapy of neonatal M. morganii infection are discussed.Risk factors in the mother included having a cervical cerclage in place and treatment with dexamethasone and prophylactic ampicillin. The major risk factors in the infant were maternal chorioamnionitis and extreme prematurity. The mother responded to treatment with ampicillin, metronidazole, and gentamicin following delivery and had an uncomplicated recovery. Her infant developed severe early onset M. morganii infection complicated by neutropenia, thrombocytopenia, and severe acidosis and expired. Postmortem cultures of pleural fluid, peritoneal fluid, and blood were positive despite treatment with gentamicin, an antibiotic to which the organism was sensitive.M. morganii may cause serious infection in pregnancy and in the neonatal period. The use of dexamethasone and prophylactic ampicillin may have increased the risk of infection with this ampicillin-resistant organism. The failure of gentamicin to sterilize the infant's blood and body fluids emphasizes the necessity of treating such infections with a combination of an aminoglycoside and a third-generation cephalosporin, such as cefotaxime. |
| Databáze: | OpenAIRE |
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