Impact of highly active antiretroviral treatment on expression of HIV-1 coreceptors and ligand levels in peripheral blood from HIV-1 infected patients in China
| Autor: | Lijuan Wu, Chaojun Wang, Jiajie Fang, Shi Bai, Xiaolin Yao, Xuanwen Zhu, Changzhong Jin |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Chemokine China Receptors CXCR4 Receptors CCR5 Anti-HIV Agents Human immunodeficiency virus (HIV) Gene Expression HIV Infections CD8-Positive T-Lymphocytes medicine.disease_cause Biochemistry CXCR4 Antiretroviral Therapy Highly Active medicine Antiretroviral treatment Humans Lymphocyte Count biology business.industry Biochemistry (medical) Disease progression virus diseases Cell Biology General Medicine Middle Aged Virus Internalization Ligand (biochemistry) Virology Peripheral blood Case-Control Studies Chemokines CC Immunology biology.protein HIV-1 Female business Chemokines CXC |
| Zdroj: | The Journal of international medical research. 41(5) |
| ISSN: | 1473-2300 |
| Popis: | Objective Coreceptors are important for HIV-1 entry into target cells and disease progression. The impact of HIV-1 and highly active antiretroviral treatment (HAART) on coreceptor expression has been little studied. Methods Expression of C–C chemokine receptor (CCR) 5 and C–X–C chemokine receptor (CXCR) 4 on CD4+ and CD8 + T cells was compared in HIV-1-infected individuals who had/had not received HAART, and in healthy controls. Relationships between coreceptors and their chemokine ligands were studied. Results This study included 23 controls and 88 HIV-1-infected individuals, 35 of whom were HAART naïve. Percentages of CCR5 and CXCR4+ CD8 + T cells were higher, and CXCR4+ CD4 + T cells were lower, in patients than in controls. Patients receiving HAART showed a higher percentage of CCR5 expression on CD4 + T cells compared with HAART-naïve patients. HIV-infected individuals had significantly increased levels of peripheral ligands for coreceptors, compared with controls; levels were significantly higher in those receiving HAART compared with the HAART-naïve. Conclusions HIV-1 infection increases coreceptor expression on T cells; HAART increases CCR5 expression further and decreases CXCR4 expression, reversing the switch from CCR5 to CXCR4, which was significant for CD4 + T. |
| Databáze: | OpenAIRE |
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