Association of Adiponectin Polymorphism with Metabolic Syndrome Risk and Adiponectin Level with Stroke Risk: A Meta-Analysis
| Autor: | Fu-Gang Che, Xing-Hui Li, Xiao-Quan Zhu, Jia Chunyuan, Liang Sun, Hui-Ping Yuan, Fan Yang, Han Jing, Ze Yang |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Risk medicine.medical_specialty Disease 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Metabolic Diseases Internal medicine Genetic model Confidence Intervals Odds Ratio medicine Humans Genetic Predisposition to Disease Metabolic Syndrome Multidisciplinary Adiponectin business.industry Odds ratio medicine.disease Confidence interval Stroke Endocrinology Meta-analysis Relative risk Female Metabolic syndrome business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Many previous studies have provided evidence that the ADIPOQ +45T>G polymorphism (rs2241766) might cause metabolic syndrome (MS). As a cardiovascular manifestation of MS, the incidence of stroke is associated with adiponectin; however, the results remain controversial and inconsistent. Systematic searches of relevant studies published up to Dec 2014 and Jan 2016 on the ADIPOQ +45T>G polymorphism and the risk of MS and adiponectin levels and the risk of stroke, respectively, were conducted in MEDLINE and EMBASE. The odds ratio (OR) or risk ratio (RR) and their 95% confidence interval (95% CI) were extracted. Sixteen studies containing 4,113 MS cases and 3,637 healthy controls indicated a weak positive association between ADIPOQ +45 T>G and MS in the dominant genetic model (OR = 1.30, 95% CI = 1.03–1.65), which was also validated by stratified subgroup analyses. Twelve studies including 26,213 participants and 4,246 stroke cases indicated that 5 μg/ml increments in adiponectin level were not relevant to stroke risk (RR = 1.05, 95% CI = 1.00–1.10, P = 0.069). This study suggested a weak positive association of ADIPOQ +45T>G with MS and a strong association with metabolic-related disease. Additionally, adiponectin level was not a causal factor of increasing stroke risk. |
| Databáze: | OpenAIRE |
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