More than just acral melanoma: the controversies of defining the disease
| Autor: | Héctor Martínez-Said, Aretha B Nobre, Carla Daniela Robles-Espinoza, David E. Elder, Patricia A. Possik, David J. Adams, Sara Santos Bernardes, Ingrid Ferreira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Skin Neoplasms Review Disease Acral lentiginous melanoma Pathology and Forensic Medicine Epidemiology Biomarkers Tumor medicine Pathology Animals Humans RB1-214 genetics skin and connective tissue diseases Melanoma Nail Apparatus Dermatologie integumentary system Foot business.industry Hand medicine.disease Dermatology Hairless acral melanoma Nails Anatomopathologie Acral melanoma Cutaneous melanoma histopathology Histopathology epidemiology prognosis business |
| Zdroj: | The Journal of Pathology: Clinical Research, Vol 7, Iss 6, Pp 531-541 (2021) The Journal of Pathology: Clinical Research |
| ISSN: | 2056-4538 |
| Popis: | Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with unique morphological and structural features. Despite clear definitions, the misuse of these terms and the inconsistency in reporting the histopathological features of AM cases have become a major obstacle to the study of the disease. In this review, we discuss the epidemiology, histopathological features, prognosis, and genetic profile of AM, highlighting the differences observed when histopathological subtypes are considered. The increasing global effort to characterise AM cases from ethnically diverse populations would benefit greatly from a more consistent classification of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text