Antiinflammatory investigation of some species ofMikania
| Autor: | E. Reche, Elfrides Eva Scherman Schapoval, Fabiane M. Farias, Célia G. Chaves, A. T. Henriques, Edna Sayuri Suyenaga |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Leukocyte migration Anti-Inflammatory Agents Decoction Mikania Asteraceae Pharmacognosy Carrageenan law.invention Oral administration law medicine Animals Edema Rats Wistar Pleurisy Inflammation Pharmacology Plant Stems Traditional medicine biology Plant Extracts business.industry biology.organism_classification medicine.disease Hindlimb Rats Plant Leaves Cell Migration Inhibition Pleura Phytotherapy business Brazil |
| Zdroj: | Phytotherapy Research. 16:519-523 |
| ISSN: | 1099-1573 0951-418X |
| Popis: | Mikania laevigata Schultz Bip. ex Baker, M. involucrata Hook. et Arn. and M. hirsutissima DC. (Asteraceae), commonly occurring in the southern Brazilian State of Rio Grande do Sul, were submitted to biological tests to evaluate their potential antiinflammatory activity. Decoctions from the leaves and stems were analysed by the induced rat paw oedema and pleurisy models. The animals were treated orally with different decoction doses. In the induced rat paw oedema test, the animals treated with leaf decoctions from M. laevigata (200 mg/ kg) and M. involucrata (50 mg/ kg) presented an oedema inhibition of 81.56% and 81.67%, respectively, 3 h after the administration of the phlogistic agent. Leaf decoctions from M. hirsutissima (400 mg/ kg) did not show such an activity. Stem decoctions displayed lower antiinflammatory activity when compared with the same doses and response time of the leaf decoctions for all analysed species. In the pleurisy assay, leaf decoctions from M. laevigata (400 mg/ kg) and M. involucrata (200 mg/ kg) inhibited leukocyte migration to the pleural exudate by 28.26% and 54.35%, respectively. |
| Databáze: | OpenAIRE |
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