Polymetallic Complexes for Applications as Photosensitisers in Anticancer Photodynamic Therapy
| Autor: | Felder, Patrick S., Keller, Sarah, Gasser, Gilles |
|---|---|
| Přispěvatelé: | Institute of Chemistry for Life and Health Sciences (iCLeHS), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Eruropéen ERC Grant, European Project: 681679, H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),681679,PhotoMedMet(2017) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Metals in medicine 010405 organic chemistry Chemistry medicine.medical_treatment Biochemistry (medical) Pharmaceutical Science Medicine (miscellaneous) Bioinorganic chemistry Photodynamic therapy [CHIM.THER]Chemical Sciences/Medicinal Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry eye diseases 0104 chemical sciences 3. Good health Photodynamic Therapy medicine Metals in Medicine Pharmacology (medical) Bioinorganic Chemistry Genetics (clinical) |
| Zdroj: | Advanced Therapeutics Advanced Therapeutics, Wiley, 2020, 3 (1), pp.1900139. ⟨10.1002/adtp.201900139⟩ Advanced Therapeutics, 2020, 3 (1), pp.1900139. ⟨10.1002/adtp.201900139⟩ |
| ISSN: | 2366-3987 |
| DOI: | 10.1002/adtp.201900139⟩ |
| Popis: | International audience; After the first successful clinical trials of monometallic photosensitizers (PSs) for photodynamic therapy (PDT), the use of polynuclear complexes is currently coming to the fore. These increasingly complex systems bear a high potential to overcome the drawbacks of their mononucleic peers by, for example, increasing the solubility of the PDT PSs and therefore their pharmacokinetic behavior, changing their internal quantum, and singlet oxygen efficiencies or adding supplementary imaging or therapeutical modalities, thus opening up the field for approaches in personalized medicine by combining therapy and diagnosis together in a single treatment. In this review, the most promising examples of polymetallic complexes used as PSs for anticancer PDT are presented. |
| Databáze: | OpenAIRE |
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