Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study
| Autor: | Flavia M. Cicuttini, Dallas R. English, Alicia K Heath, Yuanyuan Wang, Anita E. Wluka, Elizabeth A. Williamson, Sultana Monira Hussain, Stephen E. Graves, Graham G. Giles, Darryl W. Eyles |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
D-BINDING PROTEIN
Male medicine.medical_specialty Arthroplasty Replacement Hip CANCER-RISK Osteoarthritis Diseases of the musculoskeletal system VITAMIN-D STATUS DETERMINANTS Hip replacement (animal) Osteoarthritis Hip Cohort Studies Rheumatology OSTEOPOROTIC FRACTURES Risk Factors Internal medicine Medicine PARTICIPANTS Humans Orthopedics and Sports Medicine Prospective Studies ARTHROPLASTY Vitamin D Prospective cohort study Science & Technology business.industry Research Hazard ratio Australia TOTAL KNEE 1103 Clinical Sciences medicine.disease STEROID-HORMONE CONCENTRATIONS Orthopedics Quartile RC925-935 Joint replacement registry CARDIOVASCULAR-DISEASE Cohort Female business Life Sciences & Biomedicine Cohort study |
| Zdroj: | BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-10 (2021) BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| Popis: | BackgroundTo examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study.MethodsThis study examined a random sample of 2651 participants in the Melbourne Collaborative Cohort Study who had 25(OH)D concentrations measured from dried blood spots collected in 1990-1994. Participants who underwent total hip replacement for osteoarthritis between January 2001 and December 2018 were identified by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Cox proportional hazard regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of total hip replacement for osteoarthritis in relation to 25(OH)D concentrations, adjusted for confounders.ResultsEighty-six men and eighty-seven women had a total hip replacement for osteoarthritis. Compared with men in the lowest (1st) quartile of 25(OH)D concentration, the HR for total hip replacement was 2.32 (95% CI 1.05, 5.13) for those in the 2nd quartile, 2.77 (95% CI 1.28, 6.00) for those in the 3rd quartile, and 1.73 (95% CI 0.75, 4.02) for those in the highest quartile of 25(OH)D concentrations (pfor trend 0.02). There was little evidence of an association in women.ConclusionsHigher circulating 25(OH)D concentrations were associated with an increased risk of total hip replacement for osteoarthritis in men but not in women. Although the underlying mechanism warrants further investigation, our findings highlight the need to determine the optimal levels of circulating 25(OH)D to reduce the risk of hip osteoarthritis. |
| Databáze: | OpenAIRE |
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