Depressed Immune Response to Tetanus in Children with Vitamin A Deficiency
| Autor: | Gantira Natadisastra, Muhilal, Alan L. Scott, Lisa Mele, Alfred Sommer, Richard D. Semba, Endi Ridwan, Keith P. West, Sopandi Wirasasmita |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Vitamin Medicine (miscellaneous) Physiology Enzyme-Linked Immunosorbent Assay Placebo chemistry.chemical_compound Immune system Double-Blind Method Xerophthalmia Tetanus Toxoid medicine Humans Child Vitamin A Immunodeficiency Nutrition and Dietetics Vitamin A Deficiency Tetanus business.industry Retinol biochemical phenomena metabolism and nutrition medicine.disease Vitamin A deficiency chemistry Child Preschool Antibody Formation Immunology bacteria Female business |
| Zdroj: | The Journal of Nutrition. 122:101-107 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/122.1.101 |
| Popis: | A randomized, double-masked, placebo-controlled clinical trial was conducted with 236 preschool children, age 3-6 y, in Indonesia to assess immune status in mild vitamin A deficiency. The immune response to tetanus immunization was used as a measure of immune competence. Clinically normal children (n = 118) and children with mild xerophthalmia (n = 118) were randomly assigned to receive oral vitamin A (60,000 micrograms retinol equivalent) or placebo treatment for a total of four study groups. Two weeks after treatment, children were immunized with diphtheria-pertussis-tetanus vaccine. The immunoglobulin G (IgG) responses to tetanus at baseline and 3 wk following immunization were measured by ELISA. After adjusting for previous tetanus immunization, clinically normal and xerophthalmic children receiving vitamin A had a significantly greater IgG response to tetanus than clinically normal and xerophthalmic children receiving placebo (P less than 0.05). These results suggest that children with mild vitamin A deficiency have a relative immune depression compared with children who have been supplemented to normal vitamin A levels. |
| Databáze: | OpenAIRE |
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