ORTHOTOPIC LIVER TRANSPLANTATION IN CHILDREN WITH CHRONIC LIVER DISEASE AND SEVERE HYPOXEMIA
| Autor: | Didier Houssin, G. Grimon, Y Chapuis, J. Hobeika, Olivier Bernard, Denis Devictor |
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| Rok vydání: | 1994 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Adolescent Orthotopic liver transplantation medicine.medical_treatment Blood Pressure Liver transplantation Chronic liver disease Hypoxemia Liver Function Tests Severe hypoxemia medicine Humans Child Hypoxia Contraindication Transplantation business.industry Respiration Prognosis medicine.disease Liver Transplantation Surgery Oxygen Survival Rate Child Preschool Chronic Disease Female Morbidity medicine.symptom business Follow-Up Studies |
| Zdroj: | Transplantation. 57:224-227 |
| ISSN: | 0041-1337 |
| Popis: | Liver transplantation has been considered until recently as an absolute contraindication in hypoxemic patients. We report our experience in nine patients who had orthotopic liver transplantation between June 1986 and June 1992. These patients had cirrhosis-related hypoxemia with intrapulmonary shunting (IPS). The arterial oxygen pressure (PaO2) on room air ranged from 47 to 78 mmHg. OLT resulted in resolution of hypoxemia and closure of IPS in five patients whose hypoxemia was higher than 60 mmHg, and in death for the remaining four patients who had severe hypoxemia (PaO260 mmHg). We conclude that hypoxemia is no longer a contraindication to liver transplantation. Patients having PaO2 levels higher than 60 mmHg should have OLT as soon as possible before reaching lower levels of PaO2, and combined lung-liver transplantation or heart-lung-liver transplantation should be discussed in patients with severe hypoxemia (PaO260 mmHg). |
| Databáze: | OpenAIRE |
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