rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population
| Autor: | Meng-Meng Ou, Zao-Huo Cheng, Teng Jiang, Min-Chi Chen, Yue-Chun Zhang, Wei-Ming Ling, Zhen-He Zhou, Li-Ze Gu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Han chinese Reduced risk Single-nucleotide polymorphism Polymorphism Single Nucleotide Young Adult Asian People Polymorphism (computer science) Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Allele Genetic Association Studies Aged Genetics business.industry General Neuroscience Middle Aged Control subjects medicine.disease Minor allele frequency Schizophrenia Case-Control Studies Female Sulfotransferases business |
| Zdroj: | Neuroscience letters. 581 |
| ISSN: | 1872-7972 |
| Popis: | A recent genome-wide association study indicated that rs11098403, a single nucleotide polymorphism in the vicinity of NDST3, was strongly associated with the risk of schizophrenia in Caucasians. However, this relation has not been validated in other populations or ethnic groups. Herein, we conducted a case-control study to investigate the association of rs11098403 polymorphism with the schizophrenia risk in a Han Chinese population comprising 440 schizophrenia patients and 450 control subjects. For the first time, we showed that the minor allele (G) of rs11098403 is closely associated with a reduced risk of schizophrenia (OR=0.614; 95% CI: 0.453-0.833; P=0.002; Power=0.832). Meanwhile, the G allele of rs11098403 seemed to reduce the schizophrenia risk via a dominant manner (GG+AG vs. AA, OR=0.526; 95% CI: 0.374-0.74; P0.001). Furthermore, this association was further confirmed using an independent replication sample containing 267 schizophrenia patients and 400 control subjects with a Han Chinese descent (OR=0.652; 95% CI: 0.469-0.907; P=0.011; Power=0.772). Taken together, these findings demonstrate a significant association between rs11098403 and schizophrenia risk in Han Chinese, confirming the data that previously obtained from Caucasians. |
| Databáze: | OpenAIRE |
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