Validation of a novel risk score to predict mortality after surgery for acute type A dissection
| Autor: | Lukas Stastny, Volkmar Falk, Simone Gasser, Julia Dumfarth, Fabian Seeber, Roland Heck, Jörg Kempfert, Markus Kofler, Michael Grimm, Stephan D. Kurz, Matteo Montagner |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Risk Assessment Risk Factors Humans Medicine Hospital Mortality Aged Retrospective Studies Aortic dissection Framingham Risk Score Receiver operating characteristic business.industry Area under the curve General Medicine Perioperative Odds ratio Middle Aged medicine.disease Confidence interval Surgery Aortic Dissection Dissection Treatment Outcome Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 61:378-385 |
| ISSN: | 1873-734X 1010-7940 |
| DOI: | 10.1093/ejcts/ezab401 |
| Popis: | OBJECTIVES The aim of this study was to externally validate a lab-based risk score (lactate, creatinine, aspartate aminotransferase, alanine aminotransferase or bilirubin) by Ghoreishi et al. to predict perioperative mortality in patients undergoing surgical repair for acute type A aortic dissection. METHODS The risk score to predict operative mortality was applied to a large and homogenous validation cohort that consisted of 632 patients undergoing surgery for acute type A aortic dissection in 2 centres. Multivariable regression analysis was performed to determine the impact on survival. Receiver operating characteristics with deduced area under the curve were used to assess the ability to predict perioperative mortality. RESULTS A total of 632 patients (54% male, mean age 62 ± 14 years) were assigned to 3 different risk groups according to the calculated mortality score [low risk 20 (32.7%)]. Perioperative mortality was 8% in the low-risk group, 10% in the moderate-risk group and 24% in the high-risk group (P CONCLUSIONS The external validation process confirmed that a newly proposed risk score offers clinicians a helpful and reliable tool to improve the preoperative risk assessment of acute type A aortic dissection patients based on easily accessible and broadly available laboratory parameters. |
| Databáze: | OpenAIRE |
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