A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans
| Autor: | M, Virginia, C L, Appleyard, W L, McPheat, M J, Stark |
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| Rok vydání: | 2000 |
| Předmět: |
Aspergillus
Base Sequence Histidine Kinase biology Molecular Sequence Data Histidine kinase Regulator General Medicine Spores Fungal biology.organism_classification Aspergillus nidulans Two-component regulatory system Protein Structure Tertiary Fungal Proteins Response regulator Biochemistry Genetics Amino Acid Sequence Cloning Molecular Protein Kinases Gene Histidine |
| Zdroj: | Current Genetics. 37:364-372 |
| ISSN: | 1432-0983 0172-8083 |
| DOI: | 10.1007/s002940000123 |
| Popis: | We have characterised a-novel Aspergillus nidulans gene encoding a 'two-component' signalling protein (tcsA). tcsA encodes both a histidine kinase domain and a response regulator domain similar to those found in bacterial, lower eukaryotic and plant members of the two-component family of proteins, while two PAS domains in the amino-terminal region of the predicted tcsA product may monitor the signal which regulates a tcsA histidine kinase-response regulator phosphorelay. While tcsA is nonessential for vegetative growth, cells lacking the gene are unable to produce conidia on standard Aspergillus growth media. However, tcsA is not absolutely required for production since this defect is suppressed by growth on 1 M sorbitol. |
| Databáze: | OpenAIRE |
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