Fosfomycin tromethamine. Antibiotic of choice in the female patient: A multicenter study
| Autor: | Mohd Saleem Wani, Baldev Singh Wazir, Farzana Bashir Khan, Abdul Rouf Khawaja, Arif Hameed Bhat, Tanveer Iqbal Dar |
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| Rok vydání: | 2015 |
| Předmět: |
Pregnancy
Pediatrics medicine.medical_specialty Original Paper business.industry medicine.drug_class Urinary system fosfomycin trometamol Antibiotics Fosfomycin Tromethamine General Medicine biochemical phenomena metabolism and nutrition medicine.disease Fosfomycin trometamol asymptomatic bacteriuria (ASB) Multicenter study Lower urinary tract symptoms Internal medicine Female patient Medicine lower urinary tract symptoms urinary tract infections business |
| Zdroj: | Central European Journal of Urology |
| ISSN: | 2080-4806 |
| Popis: | Introduction The aim of this study was to evaluate oral single/multiple doses of Fosfomycin Trometamol with clinical and microbiological efficacy in:Asymptomatic bacteriuria in pregnancy.Endourological procedures.Lower urinary tract infections. Material and methods This prospective, uncontrolled, open label study was conducted in two tertiary hospitals over a period of three years. A total of 400 patients were included in the study. Group A (200 patients) with asymptomatic bacteriuria in pregnancy and Group B (200 Patients) with symptomatic lower urinary tract infections and with any day care endourological procedures were enrolled in our study. Efficacy end points like post- antibiotic urinalysis, microbiological efficacy and clinical improvement with adverse effects of the drug were evaluated. Results Of the 400 patients studied, 98% returned for follow-up. Out of the 304 urinary isolates in Table 2 (ASB and symptomatic LUTS) grown on urinary culture, majority of the isolates were Gram-negative Enterobacteriacae family. After oral single/multiple doses of fosfomycin, bacterial eradication, bacterial persistence, bacterial reinfection were 96.3%, 3.9%, 3.9% respectively (Figure 2). No isolates were grown in 8 cases (Table 2). However, on administration of the drug 23.5% patients noticed diarrhea (loose stools) followed by itching (19.7%) in genital area (Figure 1). Conclusions Fosfomycin Trometamol is a bactericidal antibiotic with a broad spectrum activity against Gram-positive also Gram-negative bacteriae. It has an advantage of oral single /multiple doses, higher eradication rate of bacteria after 48 hours, excellent tolerability and safety in pregnancy and other female age groups. We recommend Fosfomycin Trometamol as the drug of choice particularly in patients with poor drug compliance and for minor day care endourological procedures. |
| Databáze: | OpenAIRE |
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