A case of renal and splenic LECT 2 amyloidosis: A recently recognized cause of renal and systemic amyloidosis
| Autor: | Anjay Rastogi, Ramy M Hanna, Marina Barsoum, Michael Shye, Anthony Sisk, Carl Schulze, Farid Arman, Mira Mikhail |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Biopsy lcsh:Medicine Kidney Renal amyloidosis AA amyloidosis Predictive Value of Tests medicine AL amyloidosis Humans Renal Insufficiency Chronic Fibrinogen alpha chain Splenic Diseases medicine.diagnostic_test biology Staining and Labeling business.industry Beta-2 microglobulin Amyloidosis lcsh:R General Medicine Middle Aged medicine.disease Transthyretin Microscopy Electron Treatment Outcome biology.protein Intercellular Signaling Peptides and Proteins Renal biopsy business Biomarkers |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 31, Iss 2, Pp 508-514 (2020) |
| ISSN: | 1319-2442 |
| Popis: | Amyloidosis has traditionally been of a few defined varieties, most commonly including light-chain amyloidosis (AL amyloidosis) and secondary amyloidosis due to chronic inflammation (AA amyloidosis). Apolipoprotein A-I/A-II cystatin C, gelsolin, lysozyme, fibrinogen alpha chain, beta 2 microglobulin, and transthyretin familial amyloidosis represent rarer but reported varieties. Ten years ago, the first reports linked leukocyte chemotactic factor 2 (LECT2) amyloidosis as a pathological agent identified as a novel class of amyloid-generating protein. Epidemiology suggested that this was a new cause of amyloidosis that is especially common in Hispanic patients and somewhat common among patients from the Middle East-North Africa (MENA) region. We report a case of splenic and renal LECT 2 amyloidosis in a 62-year- old Hispanic male with diabetes mellitus. After an unremarkable serological workup, LECT 2 amyloidosis was diagnosed on renal biopsy. The case presentation is reviewed as a typical presentation, and the literature is reviewed regarding this newly reported entity, resulting in infiltrative renal amyloidosis and chronic renal disease. |
| Databáze: | OpenAIRE |
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