Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions

Autor:	Gean M Dal Forno, Gonçalo J. L. Bernardes, Thuany M. Ferreira, Josiel B. Domingos, Bruno L. Oliveira, Eloah Latocheski
Rok vydání:	2020
Předmět:	Molecular Structure Chemistry Mechanism (philosophy) Transition Elements Chemical biology Molecule General Chemistry Organic Chemicals Bioorthogonal chemistry Combinatorial chemistry
Zdroj:	Chemical Society Reviews. 49:7710-7729
ISSN:	1460-4744 0306-0012
Popis:	Cleavage of C-O and C-N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, under biological conditions. However, the precise mechanism of such uncaging reactions remains elusive. This review provides mechanistic insights into metal-mediated bond-cleavage reactions, with the goals of understanding the main factors that influence the reaction and aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0149d6151e1bcf3f5bd39725043c46ed https://doi.org/10.1039/d0cs00630k Zobrazit plný text záznamu