Pluripotency and growth factors in early embryonic development of mammals : a comparative approach
| Autor: | L. Llobat |
|---|---|
| Přispěvatelé: | Producción Científica UCH 2021, UCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos |
| Rok vydání: | 2021 |
| Předmět: |
Veterinary medicine
medicine.medical_treatment Cellular differentiation molecular mechanisms Crecimiento - Factores embryo Review Biology Expresión génica Developmental biology Mammals - Embryology 03 medical and health sciences 0302 clinical medicine SF600-1100 growth factors Gene expression mammalian medicine Blastocyst Mamíferos - Embriología Células germinales development Gene 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine General Veterinary Cell growth Growth factor Embryogenesis Embryo Germ cells Growth factors pluripotency Cell biology medicine.anatomical_structure Biología del desarrollo gene expression |
| Zdroj: | CEU Repositorio Institucional Fundación Universitaria San Pablo CEU (FUSPCEU) Veterinary Sciences Veterinary Sciences, Vol 8, Iss 78, p 78 (2021) |
| ISSN: | 2306-7381 |
| DOI: | 10.3390/vetsci8050078 |
| Popis: | Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2306-7381/8/5/78 The regulation of early events in mammalian embryonic development is a complex process. In the early stages, pluripotency, cellular differentiation, and growth should occur at specific times and these events are regulated by different genes that are expressed at specific times and locations. The genes related to pluripotency and cellular differentiation, and growth factors that determine successful embryonic development are different (or differentially expressed) among mammalian species. Some genes are fundamental for controlling pluripotency in some species but less fundamental in others, for example, Oct4 is particularly relevant in bovine early embryonic development, whereas Oct4 inhibition does not affect ovine early embryonic development. In addition, some mechanisms that regulate cellular differentiation do not seem to be clear or evolutionarily conserved. After cellular differentiation, growth factors are relevant in early development, and their effects also differ among species, for example, insulin-like growth factor improves the blastocyst development rate in some species but does not have the same effect in mice. Some growth factors influence genes related to pluripotency, and therefore, their role in early embryo development is not limited to cell growth but could also involve the earliest stages of development. In this review, we summarize the differences among mammalian species regarding the regulation of pluripotency, cellular differentiation, and growth factors in the early stages of embryonic development. |
| Databáze: | OpenAIRE |
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